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<!DOCTYPE html>
<html lang='en'>
<head>
<meta charset='utf-8'>
<meta name='viewport'
content='width=device-width, initial-scale=1.0'>
<title>Molecular Evolution Simulator for Amino Acids</title>
<link rel='shortcut icon' href='favicon.png' type='image/png'>
<link rel='stylesheet' href='style.css'>
<link rel='stylesheet' media='only screen'
href='mobile.css'>
<link rel='stylesheet' media='only screen and (min-width: 768px)'
href='tablet.css'>
<link rel='stylesheet' media='only screen and (min-width: 1024px)'
href='desktop.css'>
<link rel='stylesheet' media='only print'
href='print.css'>
</head>
<body>
<ol id='genome-history' start='0'></ol>
</ol>
<div id='instructions'>
<div id='die'>
<div class='value'>--</div>
<button class='roll' disabled=''>Roll</button>
</div>
<span id='remaining-iterations'>--</span> more times:
<ol>
<li id='clone-nucleotide' class='step'>
<button id='clone' disabled=''>Clone</button> the genome to
start mutating it.
</li>
<li id='roll-for-nucleotide' class='step'>
Roll to find the nucleotide to mutate.
<ul>
<li>If the roll is between 1 through 18, inclusive, select
that nucleotide.</li>
<li>Otherwise, skip mutation and clone the genome
again.</li>
</ul>
</li>
<li id='nucleotide-select' class='step'>
Select the <span id='select-number'>rolled</span>
nucleotide in the sequence.
</li>
<li id='roll-for-mutation' class='step'>
Roll to see what kind of mutation to perform.
</li>
<li id='perform-mutation' class='step'>
Depending on the roll:
<ul>
<li>If the roll is between 1 through 14, inclusive, perform
a <em>transition</em> on the selected nucleotide.</li>
<li>If the roll is between 15 through 17, inclusive,
perform a <em>complementing transversion</em> on the selected
nucleotide to the base it pairs with.</li>
<li>Otherwise, perform the <em>other transversion</em> on
the selected nucleotide.</li>
</ul>
</li>
<li id='amino-acid-select' class='step'>
Select the correct amino acid for the new codon.
</li>
<li id='mark-as-lethal'>
Depending on the change to the codon:
<ul>
<li>If the mutation caused a change in the amino acid being
coded, mark this mutation as <em>lethal</em>, and start
over with the genome from the previous iteration.</li>
<li>Otherwise, mark the mutation as <em>non-lethal</em>,
and continue with this new genome.</li>
</ul>
</li>
</ol>
<p id='print-results' class='step'>
<button id='print' disabled=''>Print</button> results.
</p>
</div>
<div id='errors' class='hidden'>
<p></p>
<button>OK</button>
</div>
<ul id='nucleotide-selector' class='hidden'>
<li>A</li>
<li>G</li>
<li>C</li>
<li>T</li>
</ul>
<div id='amino-acid-selector' class='hidden'>
<p>Select the amino acid for the codon <span class='codon'>--</span></p>
<ul>
<li>Ala</li>
<li>Arg</li>
<li>Asn</li>
<li>Asp</li>
<li>Cys</li>
<li>Gln</li>
<li>Glu</li>
<li>Gly</li>
<li>His</li>
<li>Ile</li>
<li>Leu</li>
<li>Lys</li>
<li>Met</li>
<li>Phe</li>
<li>Pro</li>
<li>Ser</li>
<li>Thr</li>
<li>Trp</li>
<li>Tyr</li>
<li>Val</li>
<li>STOP</li>
</ul>
</div>
<div id='lethality-selector' class='hidden'>
<button id='lethal'>Lethal</button>
<button id='non-lethal'>Non-lethal</button>
</div>
<script src='main.mjs' type='module'></script>
</body>
</html>
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